Angioedema refers to a localised area of swelling affecting the subcutaneous and submucosal tissues due to release of vasoactive peptides, such as histamine or bradykinin. Despite being a relatively common presentation in the emergency room, the diagnosis can present a challenge to many healthcare professionals. Several conditions presenting with muco-cutaneous swellings may be misdiagnosed as angioedema. This article aims to provide an overview of the typical hallmarks of angioedema alongside its aetiology. We provide an overview of angioedema mimics that might potentially lead to misdiagnosis and highlight key features that help distinguish these conditions from angioedema. This is further illustrated with two interesting cases erroneously labelled as angioedema.