Volume 20

A rare, but life-threatening sore throat: A case of Lemierre’s syndrome

We present the case of a previously healthy, immunocompetent male with Lemierre’s Syndrome. He presented with headache, sore throat and pyrexia. Initial blood tests revealed raised inflammatory markers and electrolyte abnormalities. Blood cultured Fusobacterium necrophorum. He developed respiratory distress and imaging confirmed lung abscess and empyema due to septic emboli. He required surgical drainage and a prolonged course of antibiotics. This case highlights the rare, but life-threatening condition of Lemierre’s Syndrome. We discuss the importance of prompt recognition and early antibiotic therapy.

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Idiopathic systemic capillary leak syndrome (Clarkson’s disease) presenting with recurrent hypovolemic shock

A 49-year old male with a past medical history of myocardial infarction and compartment syndromes requiring fasciotomies presented on five occasions with hypovolemic shock. We describe his admissions and presumptive diagnoses which required large volumes of intravenous fluids, admission to intensive care for vasopressors and renal replacement therapy. The presentations were always precipitated by a prodrome of fatigue and pre-syncopal episodes. On his last admission, a diagnosis of Idiopathic systemic capillary leak syndrome (ISCLS), also known as Clarkson’s Disease, was reached. He is currently receiving high dose intravenous immunoglobulins on a monthly basis.

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Heart failure from thyrotoxicosis due to Graves’ disease

A 30-year-old female patient with a past medical history of pernicious anaemia presented with pleuritic chest pain, palpitations, fatigue, coryzal symptoms and a high temperature. She was hypoxic and tachycardic and was extensively investigated as well as aggressively treated. A type 1 ‘gut feeling’ assessment by the admitting medical registrar made the diagnosis possible as thyroid function tests were grossly deranged and pointed to Graves’ disease causing heart failure, complicated by pneumonia. The patient was discharged on carbimazole, antibiotics and beta blockers. Due to a resultant thrombocytopaenia, she has now been swapped onto propylthiouracil and is under active follow up.

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The evidence for assessing frailty and sarcopenia in an acute medical unit: a systematic review

Background/objectives: A systematic review was conducted to assess if frailty and sarcopenia were associated with poorer outcomes in older adults admitted to an acute medical unit (AMU).

Methods: Eligible studies included older adults with an unplanned admission to an AMU and included a measure of frailty or sarcopenia, completed within 72 hours of admission. Risk of bias was assessed.

Results: Of 1659 identified articles, 16 were included (4 on sarcopenia and 12 on frailty). There was significant study heterogeneity. Overall, frailty and sarcopenia were associated with worse outcomes. Targeted interventions appeared to improve outcomes.

Conclusion: Current evidence suggests some benefit in screening older adults admitted to an AMU for frailty and sarcopenia. However, further studies are required before clinical adoption.

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Evaluating quality in acute care using patient reported outcome measures: a scoping review

The aim of this scoping review is to identify patient reported outcome measures (PROMs) in acute care settings, assess their psychometric properties and provide recommendations for their use in daily practice. We performed a search in the PubMed database to identify publications concerning PROMs in an acute care setting. The COSMIN checklist was used to assess the psychometric properties of the reported PROMs. We found 1407 publications and included 14 articles, describing 15 measures. Most publications provided limited information on psychometric properties. Three generic PROMs were deemed of adequate quality for use in acute care. We recommend future development and evaluation of PROMs focussing on acute care to further evaluate and improve the quality of acute care.

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Hospital trainees’ worries, perceived sufficiency of information and reported psychological health during the COVID-19 pandemic

Introduction: The COVID-19 pandemic has been unsurpassed in clinical severity or infectivity since the 1918 Spanish influenza pandemic and continues to impact the world. During the A/H1N1 pandemic, healthcare workers presented concerns regarding their own and their families’ health, as well as high levels of psychological distress. We aim to assess hospital trainees’ concerns, perceived sufficiency of information, behaviour and reported psychological health during the COVID-19 pandemic.

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Diagnoses and mortality in a population without acute myocardial infarction, but with elevated highsensitive troponin I – a retrospective register-based single center study

Aim: To explore, which differential diagnoses to consider in individuals with elevated troponins without acute myocardial infarction (AMI), and the mortality for those individuals.

Methods: Retrospective, register-based study on a representative sample of the Danish population with the following inclusion criteria: High-sensitive troponin I (hs-TnI) ≥25 ng/L, age ≥18 years, and exclusion of AMI.

Results: 3067 individuals without AMI but increased hs-TnI were included. Most frequent discharge diagnoses: Pneumonia (12.8%), Aortic valve disorder (11.3%), Medical observation (10.9%) and Heart failure (8.9%). The 30-days and one-year mortality was 15.8% and 32.0%, respectively.

Conclusions: A selected number of alternative diagnoses must be considered in individuals with increased hs-TnI. Due to high mortality it is crucial to carefully evaluate these individuals despite the absence of AMI.

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Does thrombolysis for pulmonary embolism reduce the risk of chronic complications?

We assessed the efficacy of thrombolysis in avoiding long-term complications.

Notes of patients thrombolysed for PE in the 2-year period were reviewed. The initial CTPA and echocardiogram results before thrombolysis were compared to the results of follow up imaging repeated after 6 months.

Twenty-two patients were thrombolysed for PE. 14 patients had sub-massive PE and 8 patients had massive PE. The right ventricle (RV) was dilated on pre-thrombolysis echocardiogram in 16 patients.

On follow up echocardiography all patients with massive PE (6 studies) had a normal RV size, with pulmonary artery pressures (PAP) of 29mmHg. Follow up echocardiography of patients with submassive PE (13 studies) showed 11 patients with a normal RV, with PAP of 28 mmHg.

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Predicting poor outcome in patients with suspected COVID-19 presenting to the Emergency Department (COVERED) – Development, internal and external validation of a prediction model

Background: A recent systematic review recommends against the use of any of the current COVID-19 prediction models in clinical practice. To enable clinicians to appropriately profile and treat suspected COVID-19 patients at the emergency department (ED), externally validated models that predict poor outcome are desperately needed.

Objective: Our aims were to identify predictors of poor outcome, defined as mortality or ICU admission within 30 days, in patients presenting to the ED with a clinical suspicion of COVID-19, and to develop and externally validate a prediction model for poor outcome.

Methods: In this prospective, multi-centre study, we enrolled suspected COVID-19 patients presenting at the EDs of two hospitals in the Netherlands. We used backward logistic regression to develop a prediction model. We used the area under the curve (AUC), Brier score and pseudo-R2 to assess model performance. The model was externally validated in an Italian cohort.

Results: We included 1193 patients between March 12 and May 27 2020, of whom 196 (16.4%) had a poor outcome. We identified 10 predictors of poor outcome: current malignancy (OR 2.774; 95%CI 1.682-4.576), systolic blood pressure (OR 0.981; 95%CI 0.964-0.998), heart rate (OR 1.001; 95%CI 0.97-1.028), respiratory rate (OR 1.078; 95%CI 1.046-1.111), oxygen saturation (OR 0.899; 95%CI 0.850-0.952), body temperature (OR 0.505; 95%CI 0.359-0.710), serum urea (OR 1.404; 95%CI 1.198-1.645), C-reactive protein (OR 1.013; 95%CI 1.001-1.024), lactate dehydrogenase (OR 1.007; 95%CI 1.002-1.013) and SARS-CoV-2 PCR result (OR 2.456; 95%CI 1.526-3.953). The AUC was 0.86 (95%CI 0.83-0.89), with a Brier score of 0.32 and, and R2 of 0.41. The AUC in the external validation in 500 patients was 0.70 (95%CI 0.65-0.75).

Conclusion: The COVERED risk score showed excellent discriminatory ability, also in external validation. It may aid clinical decision making, and improve triage at the ED in health care environments with high patient throughputs.

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Editorial – Managing Risk in Uncertain Times

In February 2021 Jon Hilton (AIM ST4 doctor) published a tweet asking about how the Acute Medicine community can best address potential applicant’s fears of dealing with clinical risk. ​(1)​ Appraising and managing risk is at the core of acute medical clinical practice; we treat patients in the first crucial 24 hours of their hospital journey, when the clinical status is changeable, and the clinical trajectory not yet established. We make judgement calls about medical treatment, but also about whether a patient can be safely discharged home, and this often causes anxiety amongst less experienced clinicians: how do you make that call?

Dealing with risk can be tricky to teach. It is a skill that stands on two legs: one leg is data and the other is clinical experience. As the pandemic intensified, Acute Medicine’s role as front door risk managers became more important than ever before. We displayed massive amounts of creativity and initiative to develop pathways and processes to ensure patients were followed up at home. But we were still operating with many unknown variables and did not yet have the experience nor the data required to make the crucial risk calculations and judgement calls that forms the heart of our working practice. Long before we began to recognise patterns in our patients in their diseases, and before we began to create a new language to describe and communicate what we were seeing – the ‘happy hypoxic’ and the ‘day-10 wobble’ – we operated in a form of darkness, making the best decisions we could.

One year and two COVID-19 peaks later, we are better able to make nuanced decisions about patient risk, and reach collaborative plans with our patients, as the international COVD-19 academic library grows and elaborates. In this issue Azijli et al ​(2)​ present the findings of the COVERED trial, which establishes a validated model that predicts poor outcomes in patients in the Emergency Department. This model is a tool that can help power our risk perception and clinical decision-making on the medical take.

Deciding whether to thrombolyse an acute pulmonary embolism is another exercise in risk management. Weighing the risk of death from obstructive shock against death from haemorrhage, whilst remaining mindful of the longterm cardiopulmonary sequel of an untreated high-risk PE. Apsey et al ​(3)​ followed up patients with massive and sub-massive emboli who received emergency thrombolytic therapy and favour an acute thrombolysis strategy in their conclusion. This is a small study, but provides some substrate for reflection: how do we perceive the risks of thrombolysis in out own institutions, and how does the effect our patient care?

It is not uncommon for physicians to be given a troponin results that they did not want nor request, but must now square away with their assessment and evaluation of a patient. Most of us shrink away from the descriptor ‘troponin-positive chest pain’ as a not-quite diagnosis, but when we have ruled out acute myocardial infarction, what conditions remain under this umbrella term? Hansen et al ​(4)​ describe the common conditions that lead to elevated troponin levels, and – crucially – tell us about these patients’ outcomes. Their paper shows us that patients with a high troponin, without an acute MI, have a very high mortality. This brings us back to risk: how do we keep these patients safe?

The pandemic has brought dramatic changes into our clinical and personal lives. Our trainee doctors have undergone rapid redeployments to new work environments. They often moved from low-risk to high-risk COVID-19 environments with very little notice. Some of them became very sick with COVID-19. They have had expensive and mandatory examinations cancelled. Many have been left with uncertain futures, not knowing if they will be able to progress with their training programmes as anticipated. Aziminia et al ​(5)​ have captured their voice in this issue, and make suggestions toward helping trainees navigate this incredibly uncertain period in their medical careers.

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