A 30-year-old female patient with a past medical history of pernicious anaemia presented with pleuritic chest pain, palpitations, fatigue, coryzal symptoms and a high temperature. She was hypoxic and tachycardic and was extensively investigated as well as aggressively treated. A type 1 ‘gut feeling’ assessment by the admitting medical registrar made the diagnosis possible as thyroid function tests were grossly deranged and pointed to Graves’ disease causing heart failure, complicated by pneumonia. The patient was discharged on carbimazole, antibiotics and beta blockers. Due to a resultant thrombocytopaenia, she has now been swapped onto propylthiouracil and is under active follow up.
References
- Devereaux, D. Tewelde, SZ. Hyperthyroidism and thyrotoxicosis. Emerg Med Clin North Am 2014; 32(2): 277–92.
- https://www.uptodate.com/contents/disorders-that-causehyperthyroidism (accessed 3.3.2020).
- Brent GA. Clinical practice. Graves’ disease N Engl J Med 2008;358(24): 2594–605
- https://www.uptodate.com/contents/pathogenesis-of-gravesdisease?search=graves%20disease&topicRef=7872&source=see_link (accessed 3.3.2020).
- https://www.uptodate.com/contents/overview-of-the-clinicalmanifestations-of-hyperthyroidism-in-adults?search=hyperthyroidism&source=search_result&selectedTitle=2~150&usage_type=default&display_rank=2 (accessed 3.3.2020).
- Ertek S, Cicero AF. Hyperthyroidism and cardiovascular complications: a narrative review on the basis of pathophysiology. Arch Med Sci 2013; 9(5): 944–52. doi:10.5114/aoms.2013.38685
- Albakri A. Thyrotoxic heart failure: A review of clinical status and meta-analyses of electrocardiogram diagnosis and medical clinical management methods. Integr Mol Med 2018; 5: doi: 10.15761/IMM.1000350.
- Siu CW, Incidence, clinical characteristics and outcome of congestive heart failure as the initial presentation in patients with primary hyperthyroidism. Heart 2007; 93(4): 483–7. doi: 10.1136/hrt.2006.100628.
- Lam CSP. Mortality associated with heart failure with preserved vs reduced ejection fraction in a prospective international multiethnic cohort study. Eur Heart J 2018; 39(20): 1770–1780. doi:10.1093/eurheartj/ehy005.
- Ross DS, Burch HB, Cooper DS, et al. American Thyroid Association guidelines for diagnosis and management of hyperthyroidism and other causes of thyrotoxicosis. Thyroid 2016;26: 1343–1421.
- https://www.uptodate.com/contents/graves-hyperthyroidismin-nonpregnant-adults-overview-of-treatment#H8 (accessed4.3.2020)
- Wiersinga WM. Propranolol and thyroid hormone metabolism, Thyroid 1991; 1(3): 273–7 doi: 10.1089/thy.1991.1.273.
- Ponikowski P. ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. European Heart Journal 2016; 37:2129–200. doi:10.1093/eurheartj/ehw128.
