Abstract
Outpatient antibiotic therapy (OPAT) is being developed and practised in an increasing number of acute hospitals within the United Kingdom. This article is a review of the OPAT service delivered by a large inner city hospital over the last two years. The service demonstrates the key elements of OPAT demonstrating different delivery models, aspects of patient selection, spectrum of infections treated, choice and delivery of antimicrobials, efficacy, patient safety, outcomes, and the cost-effectiveness of this programme.
[download-attachments container="div" style="list" display_icon="1" display_count="1" display__size="0"]
References
- Rucker RW, Harrison GM. Outpatient intravenous medications in the management of cystic fibrosis. Pediatrics 1974; 54: 358–360.
- Winter RJD, George R, Deacock S, et al. Self-administered home intravenous antibiotic therapy in bronchiectasis and adult cystic fibrosis. Lancet 1984; 1: 1338–9.
- Antoniskis A, Anderson BC, Van Volkinburg EJ, et al. Feasibility of outpatient self-administration of parenteral antibiotics. West J Med 1978; 128: 203–206.
- Stiver HG, Telford GO, Mousey GM et al. Intravenous antibiotic therapy at home. Annal Internal Med 1978; 89: 690–693.
- Tice AD, Rehm SJ, Dalovisio JR et al. Practice guidelines for outpatient parenteral antimicrobial therapy. Clinical Infectious Diseases 2004; 38: 1651–72.
- Singh MK, Tonks KG, Langford NJ, et al. Deep vein thrombosis assessment clinic: evaluation of a new working practice. Acute Medicine 2005: 4; 64–67.
- Data from OPAT Outcomes Registry (available at http://www.opat.com)
- Poretz DM, Eron LJ, Goldenberg RI, et al. Intravenous therapy in an outpatient setting. JAMA 1982; 248: 336–339.
- Seccombe AW, Tonks KG, Singh MK, et al. Developing out-patient antibiotic therapy. Poster presented at UK OPAT Project (British Society for Antimicrobial Chemotherapy-22nd October 2009)
- Chapman AL, Dixon S, Andrews D, et al. Clinical efficacy and costeffectiveness of outpatient parenteral antibiotic therapy (OPAT): a UK perspective. J Antimicrob Chemotherapy 2009Dec; 64(6): 1316–24.
- Nathwani D. The management of skin and soft tissue infections: outpatient parenteral antibiotic therapy in the United Kingdom. Chemotherapy 2001; 47Suppl 1: 17–23.
