Abstract
We report two recent cases of tricyclic antidepressant (TCA) overdose complicated by the development of acute respiratory distress syndrome (ARDS). The previous literature documenting an association between TCAs and ARDS is reviewed. We propose that the respiratory complications of TCA overdose should be more widely publicised and included in national toxicology databases.
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References
- Flaherty J J, Cerva D, Graff J; ARDS associated with massive imipramine overdose Am J Emerg Med 1986; 4: 195–97.
- Kerr G W, McGuffie A C, Wilkie S; Tricyclic antidepressant overdose: a review Emerg Med J 2001; 18: 236–241.
- Tricyclic Antidepresant Overdose – Features and Management [online] 2008; Available: www.toxbase.org [accessed 15/09/08]
- Leaver S K, Evans T W; Acute Respiratory Distress Syndrome British Medical Journal 2007; 335 (7616): 389–394.
- Bernard G R, Artigas A, Brigham K L et al; The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination Am J Respir Crit Care Med 1994; 149(3): 818–24.
- Marshall A, Moore K; Pulmonary disease after amitriptyline overdosage. British Medical Journal 1973; 1: 716–717.
- Roy T M, Ossorio M A, Cipolla L M et al; Pulmonary Complications After Tricyclic Antidepressant Overdose Chest 1989; 96: 853–856.
- Varnell R M, Godwin J D, Richardson M L, et al; Adult Respiratory Distress Syndrome from Overdose of Tricyclic Antidepressants Radiology 1989; 170: 667–670.
- Lindström F D, Flodmark O, Gustafsson B; Respiratory distress syndrome and thrombotic non-bacterial endocarditis after amitriptyline overdose Acta Med Scand 1977; 202: 203–12.
- Dahlin K L, Lastbom L, Blomgren B, et al; Acute Lung Failure Induced by Tricyclic Antidepressants Toxicology and Applied Pharmacology 1997;146(2): 309–316.
