lactic acidosis

Recurrent ‘Lactic’ Acidosis-a Cautionary Tale

Case Reports, Volume 6, Issue 3, Pages 93 - 136 (2007)

Abstract

Lactic acidosis can be caused by a variety of pathological conditions. We present a case of recurrent ‘lactic’ acidosis, which was eventually diagnosed to be secondary to ethylene glycol poisoning. Though there are a handful of cases reported in the literature, it is not widely known that glycolic acid (a metabolite of ethylene glycol) is measured spuriously as lactic acid by some point of care analysers. Literature review would indicate that this is a rare but potentially confounding factor in diagnosis. Given the nature of the pathology, we would suggest that greater awareness of the problem is important.

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Metformin Associated Lactic Acidosis Not As Rare As We Think?

Case Reports, Volume 5, Issue 3, Pages 81 - 116 (2006)

Abstract

Metformin Associated Lactic Acidoisis (MALA) has been reported to be a very rare but serious side effect of metformin treatment with a fatality rate of 50%. However, with the number of patients on metformin increasing the incidence of MALA is likely to increase. We aim to raise the awareness of MALA and prompt acute physicians to consider this diagnosis in the acutely unwell diabetic patient on metformin. We present 3 cases that presented with MALA in the course of 6 months, all of whom survived. We discuss metformin, its effects and lactic acidosis. We encourage effective prompt resuscitation of these individuals to increase survival.

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