hepatitis

Delayed onset of liver injury after intentional chloroform overdose: a case report and literature review

Case Reports, Volume 18, Issue 3, Pages 137 – 204 (2019)

Chloroform is a recognised cause of acute liver injury, although now rarely encountered in clinical practice. We present a case of inhalational chloroform self-poisoning in a 47-year-old man that presented to hospital initially with reduced conscious level and later developed acute liver injury that was treated with intravenous acetylcysteine. This paper reviews the existing literature and presents a summary of the mechanisms of chloroform hepatotoxicity. Published cases show that there is a characteristic delay of 24 to 48 hours between chloroform exposure and elevation of liver transaminase activity. Therefore, clinicians need to provide an appropriate duration of monitoring in order to detect the occurrence of this important toxic effect.

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‘Non Surgical’ jaundice- how to manage on the medical take

Trainee Section, Volume 14, Issue 4, Pages 145 - 196 (2015)

Malignancy and alcoholic hepatitis are cited as the most common causes of jaundice seen in secondary care. A patient with non-alcohol related jaundice, however, may require extensive investigations and early involvement of specialists. This article utilises a case presenting to the Acute Medical Unit, (AMU) to illustrate the importance of a careful and systematic assessment of non-alcoholic related jaundice.

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Infectious Mononucleosis Hepatitis – An Unwelcome Present for Father Christmas

Case Reports, Volume 12, Issue 2, Pages 65 - 124 (2013)

Abstract

We describe a case of infectious mononucleosis (IM) hepatitis occurring in an elderly thespian, who had recently played the role of ‘Father Christmas’. We discuss the importance of differing clinical manifestations in older and younger age groups, the changing epidemiology of Epstein Barr (EB) infection within the United Kingdom and the role of different virology tests in establishing a diagnosis. Raised awareness of this changing pattern of disease could prevent unnecessary investigation and consequent potential iatrogenic complications.

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Acute Painless Jaundice: Assessment and Management

Original Articles, Volume 7, Issue 3, Pages 105 - 150 (2008)

The most common presentation of liver and biliary disease is jaundice, and most acute medical teams will encounter several jaundiced patients over time. Some of these patients will be extremely unwell, and a systematic approach will enable all doctors to manage such patients correctly.

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Simvastatin-induced myositis occurring in a patient with viral hepatitis A

A Case to Remember, Volume 3, Issue 3, Pages 85 - 128 (2004)

A 60 year old female was admitted with jaundice, malaise & loss of appetite. Two weeks before admission she had complained of diarrhoea with abdominal pain. There was no previous history of jaundice, blood transfusion or foreign travel. She denied pruritus, and stools were of normal colour, although her urine was dark. She was non-smoker & did not drink alcohol regularly. She was known to have ischaemic heart disease & hypercholestolaemia and had been taking ramipril 5mg , clopidogrel 75mg, simvastatin 20mg & omeprazole 20mg daily for the previous two years.

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