acidosis

5-Oxoproline acidosis caused by acetaminophen and flucloxacillin treatment – a case report

Case Reports, Volume 21, Issue 1, Pages 1-64 (2022)

High anion gap metabolic acidosis (HAGMA) is a common diagnosis in the emergency department, which requires a systematic work-up in order to identify and treat the underlying cause. We present an unusual case of HAGMA due to 5-oxoproline accumulation caused by prolonged treatment with both acetaminophen (paracetamol) and flucloxacillin. This paper describes the diagnostic work-up of HAGMA and emphasizes on the approach and initial treatment in case the underlying etiology is unclear.

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Paracetamol overdose presenting with hyperglycaemia, acidosis and ketonuria in a non-diabetic patient

Case Reports, Volume 8, Issue 2, Pages 51 - 94 (2009)

Abstract

There are a number of cases reported in the literature which describe hyperglycaemia in patients following paracetamol overdose. The majority of these occur in conjunction with hepatic failure. Less well known is the occurrence of hyperglycaemia and acidosis following paracetamol overdose in the absence of hepatic failure. This report describes such a case which was initially misdiagnosed as diabetic ketoacidosis (DKA).

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Paracetamol overdose presenting with hyperglycaemia, acidosis and ketonuria in a non-diabetic patient Read More

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