Sepsis- what is the role for acute medicine?

Sepsis- what is the role for acute medicine?

Introduction

Sepsis- the life-threatening response of the body to an infection- is one of the more common reasons for presentation to an Acute Medical Unit, and a major health and economic burden to our healthcare system, with an estimated 37,000 deaths occurring annually in the U.K. In the United States, recent evidence suggests that the incidence of sepsis has been rising by between 8 and 13% per annum over the last decade, and that it is now higher than that of Acute Coronary Syndrome.1 Across Europe, the cost of a hospital admission for sepsis (due to the frequent need for prolonged Critical Care admission) has been estimated at between 25,000 and 55,000 Euros.2 For the NHS, this means an estimated expenditure of £2.5 billion per year.

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References

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  11. Kumar A, Roberts D, Wood KE, et al. Duration of hypotension prior to initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Critical Care Medicine 2006; 34: 1589–96.
  12. Gaieski DF, Mikkelsen ME, Band RA, et al. Impact of time to antibiotics on survival in patients with severe sepsis or septic shock in whom early goal-directed therapy was initiated in the emergency department. Critical Care Medicine 2010; 38: 1045–53.
  13. Castellanos-Ortega A, Suberviola B, García-Astudillo LA, et al. Impact of the Surviving Sepsis Campaign protocols on hospital length of stay and mortality in septic shock patients: results of a three-year follow-up quasi-experimental study. Critical Care Medicine 2010; 38(4): 1036-43.
  14. Shorr AF, Micek ST, Welch EC, et al. Inappropriate antibiotic therapy in Gram-negative sepsis increases hospital length of stay. Critical Care Medicine 2011; 39(1): 46-51.
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  17. Bagshaw SM, Lapinsky S, Dial S, et al. Acute kidney injury in septic shock: clinical outcomes and impact of duration of hypotension prior to initiation of antimicrobial therapy. Intensive Care Medicine 2009; 35(5): 871-81.

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Sepsis- what is the role for acute medicine?

14th March 2016
PMID: 23364109
Authors Affiliations
Ron Daniels MBChB, FRCA, FFICM Consultant in Anaesthesia and Critical Care, Good Hope Hospital, Heart of England NHS Foundation Trust, Birmingham

Sepsis- what is the role for acute medicine?

Cite this article as:

Daniels R. Sepsis- what is the role for acute medicine? Acute Med. 2012;11(4):235-7. PMID: 23364109.

Sepsis- what is the role for acute medicine?

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