Abstract
Methoxydine (4-MeO-PCP) and Methoxetamine (3-MeO-2-Oxo-PCE) are both commercially produced designer drugs with structural and biochemical similarities to phencyclidine (PCP). Although phencyclidine toxicity is well documented, its recreational use in present times is rare. With the advent of new designer drugs being available widely through internet sites, Acute Physicians should be aware of the clinical features and management of these potential toxins. We present a case of methoxydine ingestion (which to our knowledge has not been previously documented in any medical journals) and a case of methoxetamine ingestion, and discuss their history, contrasting clinical features and acute management.
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References
- European Monitoring Centre for Drugs and Drug Addiction (EMCDDA). Online sales of psychoactive substances/’legal highs’: summary of results from the 2011 multilingual snapsnots. EMCDDA, Lisbon, November 2011.
- King LA. New drugs coming our way – what are they and how to we detect them? EMCDDA conference, Lisbon, 6-8 May 2009.
- Ward J, Rhyee S, Plansky J, et al. Methoxetamine: a novel ketamine analog and growing health-care concern. Clinical Toxicology 2011; 49: 874–5.
- Corazza O, Schifano F, Simonato P, et al. Phenomenon of new drugs on the internet: the case of ketamine derivative methoxetamine. Hum Psychopharmacol 2012; 27: 145–9.
- Pomarol-clotet E, Honey GD, Murray GK, et al. Psychological effects of ketamine in healthy volunteers. British Journal of Psychiatry 2006; 189: 173–179.
- Pender J. Dissociative Anaesthesia. JAMA 1971; 215: 1126-30.
- Hill SC, Thomas SH. Clinical toxicology of newer recreational drugs. Clinical Toxicology 2011; 49: 705–19.
- Hofer KE, Grager B, Muller DM, et al. Ketamine-like effects after recreational use of Methoxetamine. Ann Emerg Med 2012: published online 12 January 2012.
- Garey RE. PCP: an update. J Psychedelic drugs 1979; 11: 265–75.
- McCarron MM, Schulze BW, Thompson GA, et al. Acute PCP intoxication: Clinical patterns, complications and treatment. Ann Emerg Med 1981; 10: 290–7.
- Kalsi SS, Wood DM, Dargan PI. The epidemiology and patterns of acute and chronic toxicity associated with recreational ketamine use. Emerg Health Threats J 2011; 4: online
- Wood DM, Davies S, Puchnarewicz M, et al. Acute toxicity with the recreational use of the ketamine derivative methoxetamine. Eur J Clin Pharmacol 2012; 68: 853–6.
- Toxbase [www.toxbase.org]. Phencyclidine. [Updated March 2006; cited May 2012] Available at: http://toxbase.org/PoisonsIndex-A-Z/P-Products/Phencyclidine/
- Peace MR, Tamai LD, Potilis A. Performance evaluation of four on-site drug-testing devices for detection of drugs of abuse in urine. J Anal Toxicol 2000; 24: 589–594.
