Volume 3

Editorial

While the profile of the subspecialty of Acute Medicine continues to rise, so does the burden of work under which we are continually placed. Changes in General Practice out-of-hours cover, reduced junior doctor hours, continued pressure to achieve four hour A&E wait targets along with the arrival of yet another winter will be familiar themes for many readers. There are times when it may seem difficult to stay positive in the face of such adversity. In these moments of despair, I have recently taken to reading our ward admissions list in search of light relief. This list, compiled by non-clinical staff, describes the problems which doctors referring patients to the AMU ascribe to their patients. ‘COPD Exasperation’ appears to be a common problem (not least amongst the junior medical staff), while I hope that the patient admitted with ‘aspirations of pneumonia’ wasn’t too disappointed by his final diagnosis. A patient with Wegener’s granulomatosis was admitted several times with ‘acute f lare-up of vagueness’, an aff liction with which many of us will be familiar. My favourite, however, remains the unfortunate patient described as ‘Bilateral amputee – off legs’; things clearly could not get much worse for this man!

If your own search for light relief leads you to browse through the following pages you will find more useful reviews, case reports and the second in our ‘Controversies in acute medicine’ series. This time Guha and Sheron tackle the issue of f luid resuscitation in chronic liver disease, an area which is frequently a source of considerable confusion. I have only ever treated one patient with thyroid storm, sadly without a favourable outcome; Ben Turner’s overview of the management of this rare condition will hopefully equip readers to deal with the consequences, should you ever be faced with such a problem. At the other end of the pulse-rate spectrum, bradyarrhythmias are a more familiar on-take emergency. In part one of a series of reviews on arrhythmias to be published over the next few editions, this subject is tackled in some detail. Diarrhoea and Cardiac Arrest have both been areas traditionally avoided by consultant physicians. In these days of the ‘hands-on’ consultant (preferably gloved!), I would urge colleagues to be prepared for such eventualities by taking note of our final two reviews.

I am pleased to report that my continued pleas for submissions has resulted in more than a trickle of case reports, which has enabled us to publish two ‘Cases to remember’ in this edition. More on a similar theme would be most welcome. Mike Jones, originally brought into the editorial board for his renal expertise, wears his hat as Secretary of the SAC in General Internal Medicine to give an insight into Training developments in Acute Medicine in Viewpoint. Submissions for this section would again be welcomed.

I hope you enjoy this edition, and that you continue to find the journal helpful in your everyday practice and personal CPD into the New Year.

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Conference Report: The Society for Acute Medicine Spring Meeting – April 22nd to 23rd 2004

For this year’s spring meeting, the Society for Acute Medicine took us to Bournemouth on the sunny south coast of England. The Marsham Court Hotel served as an excellent venue for this, the ninth meeting of the society, which ran for two days over the 22nd and 23rd of April. Sunshine, the grand Pier and long stretches of raked beach augmented a relaxed and friendly atmosphere and provided a spectacular backdrop for coffee breaks between sessions.

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Benefits of an Emergency Assessment Area Medical Review Clinic: prospective evaluation

Summary

Following the establishment of a medical review clinic in an Emergency Assessment Area (EAA) the reasons for and the appropriateness of referral of patients after initial visit were prospectively analysed in 167 patients. An attempt was also made to establish the number of patients who would have been admitted if the clinic were not in place and thus the potential saving of bed-days from this new initiative. Three main reasons for referral were the uncertainty about diagnosis, uncertainty about management and the review of outstanding investigations. Fifteen per cent of patients were judged to have been inappropriately referred. In 22% of patients the presence of the clinic prevented hospital admission and it was also felt that in a further group of patients the clinic provided a useful role in reassuring the patient, reinforcing and reviewing management plans. The clinic also acted as an educational tool for junior doctors. Thus the development of an early review clinic in an Acute Medical Unit / EAA setting is a useful adjunct to the delivery of high quality ambulatory patient care.

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Controversies in acute medicine: Oxygen therapy for exacerbations of chronic obstructive pulmonary disease (COPD)

Abstract

Some patients with COPD ‘retain CO2’ when given high concentration or uncontrolled oxygen therapy. The mechanism for this, and why it occurs in only some patients, is unclear. The pathogenesis of chronic hypercapnia in COPD involves multiple, poorly understood mechanisms. During acute exacerbations ‘CO2 retention’ is thought to occur due to redistribution in ventilation-perfusion with oxygen therapy, although some studies suggest reduced ventilation also contributes. Problems arise when inexperienced staff extrapolate this teaching to include all patients with hypercapnia. The most common cause of hypercapnia is ventilatory failure. Teachers need to emphasise how to recognise ventilatory failure and the dangers of hypoxaemia in critically ill patients.

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Medical Emergencies in Human Immunodeficiency Virus (HIV) Infection

Abstract

With increasing awareness, earlier diagnosis, and aggressive use of anti-retroviral therapy, more people with HIV are living longer so that the average survival time from diagnosis is now significantly better than what it was 10 years ago. As a consequence of this, more patients with HIV are now presenting to hospitals and emergency departments as acute medical emergencies either directly related to their HIV infection, or their treatment.1 An awareness of the potential problems with which these patients can present to hospital, plus guidance on their management is essential to all acute care physicians. In this article we outline the general management of patients with HIV presenting as emergencies to hospital, and then systematically focus on some of the more common clinical problems which may arise.

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Management of Tuberculosis for the Acute Physician

Abstract

Tuberculosis is increasing world-wide and also in England and Wales, where there are marked geographical and ethnic variations. Acute physicians should be aware of this, and also of the variable manifestations of this multisystem disease, as well as current epidemiology which informs clinical risk stratification. Treatment is highly evidence based, and bacteriological confirmation should be sought whenever possible, partly because of the current level of drug resistance.

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The Emergency Management of Adult Bacterial Meningitis

Abstract

Over the last decade, new protein-conjugate vaccines against Haemophilus influenzae type b (Hib) and Neisseria meningitidis serogroup C (MenC) have had a dramatic effect on the epidemiology of childhood meningitis in the United Kingdom. Amongst adults, bacterial meningitis remains an important cause of preventable morbidity and mortality. Clinicians need to remain vigilant for the possibility of this infection. The identification of the one patient with meningitis out of many with trivial viral infections remains a difficult task. Even once the diagnosis is made clinically, the subsequent investigation and management of the patient remains controversial, with strong opinions often influenced by one or two adverse experiences. Potential improvements in the way we identify and manage meningitis patients have been identified in recent years. This review will focus on those areas relevant to the emergency care specialist. Meningitis in the immunocompromised patient often has a different clinical and epidemiological pattern and is beyond the scope of this review.

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Acute Hypoglycaemia: Diagnostic criteria, Investigation and Management for the Emergency Physician

Abstract

Hypoglycaemia is a common condition, which may easily be missed due to the variation in clinical presentation in patients with or without diabetes. The most common cause is related to the treatment of diabetes. Non-diabetes related hypoglycaemia is rare. Nonetheless, the need for careful evaluation of the underlying cause is important as well as relieving symptoms.

The diagnosis and investigations involved in management of hypoglycaemia are discussed with a direct relevance to the acute general physician.

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Editorial

Over the past three years it has become apparent to me that referring to ‘current affairs’ in these columns can be a mistake, serving only to highlight inevitable printing delays. By the time this edition arrives on your doormat Euro 2004, ‘Big Brother’ and the early summer heat wave will be nothing but a distant memory. However the ‘recent’ publication of the Royal College of Physicians document ‘Acute Medicine – making it work for patients’ cannot be allowed to pass without a mention. This report represents a significant shift in the position of the College in relation to Acute Medicine since the previous working party reported its findings in 2000. The value of consultants specialising in Acute Medicine is now clearly recognised and supported – every trust should now have one, with the minimum figure of three per hospital being proposed by 2008. Whether this is achievable will depend on the rapid development of training schemes across the UK, as well as the generation of enthusiasm for the specialty amongst junior staff. The number of applicants for our Wessex programme indicates no shortage of the latter. Although developing a training scheme takes a lot of hard work, it is vital that those already working in the specialty make this a high priority. We have already seen benefits from the appointment of high quality middle grade staff and are looking forward to a ‘flood’ of future applicants for local consultant posts, 4 years from now.

This edition comprises four more important review papers on aspects of acute medicine, along with the first in our ‘Controversies in acute medicine’ series. The latter was designed to try to stir up some correspondence, for future publication. The confusion over oxygen delivery in the acute setting seems to reign fairly widely amongst junior, and indeed some more senior medical staff. Hopefully Dr Cooper’s well-written paper will serve to dismiss some of the misconceptions in this area. Our reviews cover relatively uncommon, but nonetheless important aspects of acute medicine. Tuberculosis and HIV are both on the increase in the UK. The success of anti-retroviral therapy will undoubtedly lead HIVrelated illness to be a significant part of our practice over the next decade. An understanding of the range of conditions specific to this group of immunocompromised patients is therefore crucial for physicians involved in the acute take. Hypoglycaemia and suspected bacterial meningitis are both conditions which require immediate action by medical staff. Both of these reviews comprehensively cover their respective topics with a combination of well written text, illustrations tables and algorithms. Dr Hartman highlights recent evidence supporting the use of dexamethosone in bacterial meningitis and re-iterates some of the points made in an earlier edition regarding the use (and abuse) of CT scanning prior to lumbar puncture.

For a change we have no case reports this time, although Dr Macdonald’s audit of the innovative review clinic in the Emergency Assessment Area of Heartlands hospital provides a worthy substitute. Submission of similar articles in future would be most welcome.

Once again, a reminder that multiple choice questions are for self assessment and ‘personal’ CPD only; I hope you will find this edition helpful in your clinical practice.

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MCQ Questions for Vol.3 No.1

(H Wallis)

· The following are indications for thrombolysis in a patient presenting within 12 hours of an episode of chest pain compatible with a myocardial infarct:
1. ST elevation >1mm in 2 contiguous chest leads
2. Left bundle branch block
3. ST elevation 1mm in one limb lead
4. ST segment depression combined with raised troponin
5. Raised CK-MB with normal ECG

· Which of the following statements concerning treatments for STEMI are true?
6. Streptokinase causes a higher incidence of intracranial haemorrhage than tPA
7. Clopidogrel combined with aspirin is more effective than either drug used alone
8. Primary percutaneous coronary intervention is less effective that thrombolysis
9. Unless contraindicated all patients should be treated with intravenous beta blockade
10. Perindopril confers long-term benefit even in the absence of heart failure

(T S Leary)

· Concerning the initial management of coma
11. Intravenous glucose should only be administered if hypoglycaemia is confirmed by rapid reagent testing
12. Flumazenil may precipitate seizures
13. Absence of conjugate eye movements suggests brainstem disease
14. Bilateral dilated, reactive pupils usually indicate 3rd nerve compression
15. Glasgow coma score

· Which of the following statements is/ are true
16. A raised anion gap commonly results from lithium poisoning
17. Absence of localising motor response and roving eye movements 72 hours after cardiac arrest predicts <10% chance of functional recovery 18. Hyperthermia may accelerate neuronal damage following head injury 19. Following traumatic brain injury PaCO2 should be maintained in the range 4-4.5kPa 20. Propofol should be avoided following head injury because of its tendency to cause systemic hypotension and hence reduce cerebral perfusion pressure (N Griffin) · Which of the following reliably distinguish SAH from benign thunderclap headache? 21. Focal neurological signs? 22. Headache lasting for more than 1 hour? 23. Absence of haemorrhage on a CT performed 3 days after headache onset? 24. Absence of bilirubin in the CSF 6 hours after headache onset? 25. Absence of bilirubin in the CSF 3 days after headache onset? · Which of the statements about SAH are true? 26. 15% of SAH are not due to ruptured aneurysms. 27. Perimesencephalic haemorrhages have a better prognosis than aneurysmal SAH. 28. Most aneurysms present with sentinel headaches before they rupture. 29. The headache of SAH may develop over a few minutes. 30. Patients with SAH should be fluid restricted. (M T Bacon) · In the Patient with ‘Funny Turns’ 31. There is always a prodrome before Faintin 32. Cardiac Causes have a greater morbidity/mortality 33. There may be amnesia for any loss of consciousness 34. Falls and Syncope can overlap · Key Preliminary Investigations Include 35. Holter Monitor (24 Hour Tape) 36. Random blood sugar 37. 12 Lead ECG 38. Lying and Standing Blood Pressure · Syncope 39. Is a well recognised event after meals 40. Only occurs in the upright position 41. Does not cause incontinence 42. Has psychological sequelae · Contraindications to Syncope Testing include 43. Carotid Bruits 44. Recent Stroke 45. Previous tachyarrhthmias 46. Unable to stand for 30 minutes · Carotid Sinus Hypersensitivty exists if: 47. Massage produces sinus pause >3 seconds
48. Massage produces a BP drop of >50 mmHg
49. Massage produces symptoms without BP/HR change

· The Classical Drop Attack
50. Is preceded by Light headedness
51. Causes bewilderment in the patient
52. Is usually a result of vertebrobasilar insufficiency
53. May be due to Vasovagal syncope

(Y C Gary Lee & J O Davies)

· Regarding thoracentesis in the investigation of a pleural effusion
54. A closed pleural biopsy should always be performed at the same time
55. Atropine should be routinely administered as a premedication, unless there are contraindications.
56. Removal of a large amount of pleural f luid (eg 2 litres) can lead to re-expansion pulmonary oedema.
57. A pneumothorax on the post-thoracentesis radiograph may represent a trapped lung that fails to re-expand, rather than an airleak from puncture of the lung.
58. Ultrasound is more sensitive and accurate than clinical examination in locating the site of fluid accumulation.

· In the analysis of pleural fluid
59. Differentiating between a transudate and an exudates effusion is the important first question.
60. Pleural fluid albumin level can be useful in differentiating between an exudate and a transudate in patients receiving diuretic therapy.
61. Amylase level should be measured routinely.
62. A haemothorax is diagnosed when the effusion appeared heavily blood stained.
63. Effusions secondary to pulmonary emboli are excluded if the pleural f luid is a transudate.

· Empyema
64. Requires prompt drainage.
65. Is usually lymphocytic.
66. Is characterised by low pleural fluid pH and glucose levels.
67. Should be suspected in all patients with infective symptoms and a pleural effusion.
68. Requires surgical drainage and decortication in most cases.

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