Volume 2

Fatal pneumocystis carinii pneumonia as a complication of methotrexate in rheumatoid arthritis

Abstract

Low dose methotrexate has been used successfully to treat patients with refractory rheumatoid arthritis.1 Methotrexate-induced pneumonitis occurs in about 1 to 5% of patients, although opportunistic infections have also been reported.1 We report a case of fatal pneumocystis carinii pneumonia (PCP) in an otherwise healthy female patient treated with methotrexate for rheumatoid arthritis and review the literature.

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Delirium (acute toxic confusion) in the elderly

Abstract

Delirium (also referred to as acute confusional state or toxic confusional state) is common in elderly patients admitted to hospital, and is usually secondary to an acute physical problem rather than being a primary abnormality. Physicians caring for acutely ill patients will frequently encounter those with delirium and need to be aware of the likely precipitants as well as the optimum management. We discuss the common precipitants, the clinical features, the differential diagnosis and the management of delirium.

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Emergency assessment and management of the septic patient

Abstract

Sepsis is a common problem in hospital practice. As well as being an important precipitant of hospital admission many patients develop the problem after arrival in hospital, including in excess of 500,000 patients in critical care units across each year. Over one-half of all infections in critical care units are associated with severe sepsis or septic shock.1 Despite major research effort in this area and the introduction of new therapeutic agents, mortality from septic shock remains high (50-70%). With the ageing population, emerging antibiotic resistance, and increasing use of immunosuppressive healthcare, sepsis is set to become an even greater drain on healthcare resources. The early recognition and appropriate management of sepsis is important. There is increasing evidence that an immediate, proactive approach has prognostic significance.

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Accelerated Hypertension –management in the acute setting

Abstract

Accelerated hypertension is a rare but life threatening disease. The commonest cause is poorly controlled essential hypertension but other causes exist. Diagnosis is made by the finding of severe hypertension with associated end organ disease affecting brain, eyes, heart or kidney. Treatment should be tailored to the individual patient and usually should be given orally. There is no clear evidence that one class of antihypertensives is more effective than another and the main aim of therapy should be a controlled fall in Blood Pressure.

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Editorial

There was, no doubt, a time when the end of winter brought a sense of jubilation at the frontline of hospital medicine. Now, not only do the emergency pressures seem to continue year-round, but spring also brings the challenge of a revised set of Government targets. This April we are greeted with a 20 minute door to needle time for thrombolysis, and a four hour wait target measured from the time of arrival in A&E. Those of you who take a light-hearted view of such things may be may be amused to hear of a local hospital’s appropriately mis-spelt response in the form of a ‘Darft Action Plan’. For the rest of you, good luck – remember, your Trust’s ‘Star Rating’ is dependent on you!

In this edition, John O’Reilly reminds us that chronic obstructive airways disease accounts for up to 25% of the workload of a UK medical ‘Take’, although for the last few months it has probably felt like even more. In contrast, accelerated hypertension is rarely encountered, but nonetheless must be recognised and treated by physicians working at the front door. Two of the reviews approach contrasting presentations of the septic patient. On page 13, Cardy and Poulton have produced a comprehensive overview of the critical care perspective, while Clare Spice reminds us of the non-specific way in which infection can present in the elderly in her paper on delirium.

The ‘Regular Features’ section brings the second in a series of ‘How to do it’ papers from ophthalmologists Beth Edmonds and Peter Francis. Having covered fundoscopy last year, they now turn their attention to the demystifying of pupillary responses. This month’s ‘case to remember’ provides a salutary lesson in the need for lateral thinking in the management of patients taking immunosuppressant medication. Although a recognised complication of methotrexate therapy, the diagnosis of pneumocystis carinii pneumonia can so easily be forgotten, with potentially serious consequences.

As I have mentioned in previous editorials, I am keen to encourage submissions of case reports, audits and original research relevant to the acute medical setting for future publication. Reviews are normally commissioned in line with the cycle on page 35. However, if you have a particular interest in a condition not included in the cycle, with a relevance to other clinicians involved in the acute medical take, please feel free to write and submit to us at the address opposite, or contact me directly by e-mail.

The multiple choice questions are, once again, for self-assessment only. Answers are on the following page, so no ‘external’ CPD points can be accrued for now. However, reading the journal can still count towards your ‘personal’ CPD credit. Hopefully you will find something to interest you in the following pages, along with a little light relief from the pressures (and targets) of the ‘day-job’!

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