Volume 24, Issue 4, Pages 149 – 180 (2025)

Acute Toxicity Following Occupational Exposureto Anti-Fouling Marine Paints: A Case Series of Five Adult Patients

Introduction: Anti-fouling marine paints contain toxic components such as copper-based biocides, organotin compounds, and volatile organic solvents. Acute occupational exposure may result in respiratory, gastrointestinal, hepatic, and neurological manifestations; however, clinical data in emergency medicine regarding such exposures remain limited.
Case Presentation: Five male shipyard workers aged 23–39 years presented to the emergency department following acute occupational exposure during anti-fouling paint application. Three patients experienced inhalational exposure and presented with dyspnoea and throat irritation requiring supplemental oxygen therapy. One patient presented with nausea and vomiting and was found to have a two-fold elevation in aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels. Another patient reported dizziness, throat burning, and palpitations. Other laboratory parameters were within normal limits. All patients were hospitalised for close observation and received supportive treatment, including oxygen therapy, intravenous fluids, and symptomatic management. No severe systemic toxicity or organ failure developed. Clinical and laboratory findings improved within 72 hours, and all patients were discharged without complications.
Conclusion: Acute exposure to anti-fouling marine paints may cause heterogeneous clinical presentations, including respiratory compromise and transient hepatic enzyme elevation. Emergency physicians should recognise this occupational hazard and consider extended observation and supportive management when clinically indicated.

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Use of PERC/Wells in Combination with OtherClinical Prediction Rules to Reduce CTPA Demand in Same Day Emergency Care: A Retrospective Cohort Study

Pulmonary embolism (PE) is a common and potentially life-threatening condition encountered in acute medicine. Clinical prediction rules (CPRs), including PERC, Wells, Revised Geneva, YEARS and LEGEND, have been developed to support rational use of computed tomography pulmonary angiography (CTPA). This study evaluated whether retrospective co-application of Revised Geneva, YEARS or LEGEND alongside an existing PERC/Wells-based diagnostic pathway could reduce CTPA utilisation in a Same Day Emergency Care (SDEC) population.
We conducted a retrospective cohort study of all patients who had CTPA for suspected PE in a UK SDEC unit between January and June 2024. CPRs were applied retrospectively using documented clinical data. The primary outcomes were the potential reduction in CTPA utilisation and the proportion of scans that would have contained PE.
Of 433 CTPAs identified, 362 patients met inclusion criteria. The prevalence of PE among those scanned was 16.6%. Retrospective co-application of Revised Geneva, YEARS and LEGEND would have reduced CTPA utilisation by 5.5%, 29.0% and 39.2% respectively. No PEs were identified among scans potentially avoided using Revised Geneva, whereas PE was present in 4.8% and 5.6% of avoided scans using YEARS and LEGEND. Missed events occurred in a clinically stable ambulatory cohort and were not associated with radiological evidence of right ventricular strain; however, the clinical significance of these findings remains uncertain.
In this selected SDEC population, layering additional CPRs onto an existing diagnostic pathway may have the potential to reduce CTPA utilisation, although strategies achieving larger reductions were associated with missed diagnoses. These findings should be regarded as hypothesis-generating and require prospective validation before informing changes to clinical practice.

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Use of PERC/Wells in Combination with OtherClinical Prediction Rules to Reduce CTPA Demand in Same Day Emergency Care: A Retrospective Cohort Study Read More

Editorial – The “To LP or not to LP” conundrum. An example of the two phases of peer review and the importance of post-publication discourse

Issue 4 of the Acute Medicine Journal (AMJ) reports an interesting exchange between the authors of a service evaluation investigating the prevalence of subarachnoid haemorrhage (SAH) in patients undergoing a lumbar puncture (LP)1, and readership colleagues evaluating its merit, in light of the current evidence base and clinical recommendations2. This discourse highlights the two phases of scientific peer review, which operates as the quality control mechanism for academic publishing.

Editorial – The “To LP or not to LP” conundrum. An example of the two phases of peer review and the importance of post-publication discourse Read More

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