An Unusual Complication of Cocaine Toxicity

An Unusual Complication of Cocaine Toxicity

Abstract

A 25-year man presented to the Accident and Emergency Department complaining of dizziness and shortness of breath after taking 70 grams of cocaine over 10 hours. He said a friend had noticed that his skin had turned dark blue. On examination the patient was severely centrally and peripherally cyanosed. His pulse oximeter oxygen saturations were 88% on air. An arterial blood gas showed a methaemoglobin level of 45.6%. The patient was diagnosed with cocaineinduced methaemoglobinaemia and given methyl thioninium chloride (methylene blue). He made an uneventful recovery.

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References

  1. Price DP. Methemoglobin inducers. In: Nelson LS, et al. editors. Goldfrank’s Toxicologic Emergencies. New York: McGraw-Hill 2011; 1698-1707.
  2. rights RO, Lewander WJ, Woolf AD. Methemoglobinemia: eitiology, pharmacology and clinical management. Ann Emerg Med 1999; 34: 646-56.
  3. Gibson GR, Hunter JB, Roabe RS, et al. Methaemoglobinaemia produced by high dose intravenous nitroglycerine. Ann Intern Med 1982; 96: 615.
  4. Hunter L, Gordge L, Dargan PI, et al. Methaemoglobinaemia associated with the use of cocaine and volatile nitrites as recreational drugs: a review. Br J Clin Pharmacol; 2010; 72(1): 18-26.
  5. Guay J. Methemoglobinemia related to local anaesthetics: a summary of 242 episodes. Anesth Analg; 2009; 108: 837-45.
  6. National Poisons information service. Methaemoglobinaemia: causes and management. London: National Poisons Information Service, January 1998.
  7. Ralston AC, Webb RK, Runiciman WB. Potential errors in pulse oximetry III: Effects of interference dyes, dyshaemoglobins and other pigments. Anaesthesia 1991; 46: 291-4.
  8. Barker SJ, Tremper KK, Hyatt J, et al. Effects of Methaemoglobinaemia on pulse oximetry and mixed venous oximetry. Anaesthesiology 1997; 67: 171.
  9. National Poisons information service. (2011) Methylthioninium chloride (antidote) [online] Available at: http://www.toxbase.org [Accessed 27 November 2012

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An Unusual Complication of Cocaine Toxicity

8th March 2016
PMID: 23732133
Authors Affiliations
Lucy Houghton MBBS FY1 in Acute Medicine Stoke Mandeville Hospital Buckinghamshire
Quentin Jones MRCP SpR Respiratory Medicine Churchill Hospital, Old Road, Oxford, OX3 7LE
Chris Wathen Consultant in Respiratory Medicine Stoke Mandeville Hospital Buckinghamshire

An Unusual Complication of Cocaine Toxicity

Cite this article as:

Houghton L, Jones Q, Wathen C. An unusual complication of cocaine toxicity. Acute Med. 2013;12(2):96-7. PMID: 23732133.

An Unusual Complication of Cocaine Toxicity

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