A Challenging Case of Malignant Hypercalcaemia

A Challenging Case of Malignant Hypercalcaemia

The investigation and management of patients presenting with hypercalcaemia is not always straightforward. We describe the case of a middleaged man presenting with severe symptomatic hypercalcaemia. The difficulties encountered here - in striving for biochemical and symptom control, and in establishing a definite diagnosis - are fortunately rare. The case illustrates the range of options in the treatment of severe hypercalcaemia, and highlights the use of haemodialysis in treatmentresistant cases.
[download-attachments container="div" style="list" dipslay_icon="1" display_count="1" display__size="0"]

References

  1. Suva LJ, Winslow GA, Wettenhall RE, et al. A parathyroid hormonerelated protein implicated in malignant hypercalcaemia: cloning and expression. Science 1987; 237:893-6
  2. Mcloughlin JM, Kuhn JA, Lamont JT. Neuroendocrine tumours of the pancreas. Current Treatment Options in Gastroenterology 2004; 7: 355-364.
  3. Matsen SL, Yeo CJ, Hruban RH, et al. Hypercalcaemia and pancreatic endocrine neoplasia with elevated PTH-rp: report of two cases and subject review. J Gastrointest Surg 2005; 9(2): 270-9.
  4. Abraham P, Ralston SH, Hewison M, et al. Presentation of a PTHrpsecreting pancreatic neuroendocrine tumour, with hypercalcaemic crisis, pre-eclampsia, and renal failure. Postgrad Med J 2002; 78: 752-754.
  5. Inoue T, Nagao S, Tajima H, et al. Adenosquamous pancreatic cancer producing parathyroid hormone-related protein. J Gastroenterol 2004; 39: 176-80
  6. Bilezikian JP. Management of acute hypercalcaemia. N Eng J Med 1992; 326: 1196-203
  7. Loosdrecht AA, van Bodegraven AA, et al. Long term follow up of 2 patients with metastatic neuroendocrine tumours treated with octreotide. Neth J Med 1998; 53: 118-23
  8. Anthony LB, May ME, Oates JA. Lanreotide in the management of hypercalcaemia of malignancy. Am J Med Sci 1995; 309(6): 312-4.
  9. Camus C, Chorasse C, et al. Calcium-free haemodialysis: Experience in the treatment of 33 patients with severe hypercalcaemia. Intensive Care Med 1996; 22: 116-21

Request Permissions

To request copyright permission to republish or share portions of our works, please visit Copyright Clearance Center’s (CCC) Marketplace website by clicking the button below:

Get Permission

A Challenging Case of Malignant Hypercalcaemia

19th February 2016
PMID: 21655504
Authors Affiliations
Kate M Evans BM MRCP Specialist Registrar in Diabetes and Endocrinology Torbay Hospital, Torquay
Patric K Chong FRCP Consultant in Diabetes and Endocrinology Derriford Hospital Plymouth

A Challenging Case of Malignant Hypercalcaemia

Cite this article as:

Evans KM, Chong PK. A challenging case of malignant hypercalcaemia. Acute Med. 2006;5(1):24-6. PMID: 21655504.

A Challenging Case of Malignant Hypercalcaemia

Share this article

Click the icon of the social media platform on which you would like to share this article.


Shopping Basket
Scroll to Top