A Case of Newly Diagnosed Primary Hypothyroidism with Deteriorating Consciousness that did not Respond to Thyroxine – What Else should be Considered?

A Case of Newly Diagnosed Primary Hypothyroidism with Deteriorating Consciousness that did not Respond to Thyroxine – What Else should be Considered?

Abstract

We present an unusual case of a 60 year old male who was noted to have primary hypothyroidism and decreased consciousness which did not respond to Levothyroxine. Further investigations revealed a diagnosis of Hashimoto’s Encephalopathy which responded well to steroids. We describe the case in detail and discuss the available relevant literature on this topic.

[download-attachments container="div" style="list" display_icon="1" display_count="1" display__size="0"]

References

  1. Brain L, Jellinek EH, Ball K. Hashimoto’s Disease and Encephalopathy. Lancet 1966; 2: 512-514.
  2. Fatourechi V. Hashimoto’s Encephalopathy: Myth or Reality? An endocrinologist’s perspective. Best Pract Res Clin Endocinol Metab
    2005; 19: 53.
  3. Chong JY, Rowland LP, Utiger RD. Hashimoto encephalopathy: syndrome or myth? Arch Neurol 2003; 60: 164-171.
  4. Ferracci F, Bertiato G, Moretto G. Hashimoto’s Encephalopathy: epidemiologic data and pathogenetic considerations. J Neurol Sci 2004; 217(2): 165-8.
  5. Sawka AM, Fatourechi V, Boeve BF, et al. Rarity of encephalopathy associated with autoimmune thyroiditis: a case series from Mayo Clinic from 1950 – 1996. Thyroid 2002; 12: 393-398.
  6. Mocellin R, Walterfang M, Velakoulis D. Hashimoto’s Encephalopathy, Epidemiology, Pathogenesis and Management. CNS Drugs 2007; 21(10): 799-811.
  7. Ferlazzo E, Raffaele M, Mazzù I, et al. Recurrent status epilepticus as the main feature of Hashimoto’s Encephalopathy. Epilepsy Behav 2006; 8: 328.
  8. Mckeon A, McNamara B, Sweeney B. Hashimoto’s encephalopathy presenting with psychosis and generalised absence status. J Neurol 2004; 251: 1025.
  9. Kothbauer-Margreiter I, Sturzenegger M, Komor J, et al. Encephalopathy associated with Hashimoto thyroiditis: diagnosis and treatment. J Neurol 1996; 243: 585.
  10. Ferracci F, Carnevale A. The neurological disorder associated with thyroid autoimmunity. J Neurol 2006; 253: 975.
  11. Chaudhuri A, Behan PO. The clinical spectrum, diagnosis, pathogenesis and treatment of Hashimoto’s encephalopathy (recurrent acute disseminated encephalomyelitis). Curr Med Chem 2003; 10: 1945.

Request Permissions

To request copyright permission to republish or share portions of our works, please visit Copyright Clearance Center’s (CCC) Marketplace website by clicking the button below:

Get Permission

A Case of Newly Diagnosed Primary Hypothyroidism with Deteriorating Consciousness that did not Respond to Thyroxine – What Else should be Considered?

8th March 2016
PMID: 23732135
Authors Affiliations
Aled Williams MRCP– CT2 in General Medicine Consultant in Diabetes & Endocrinology and General Internal Medicine, Wrexham Maelor Hospital
Nikki Green MB ChB – FY2 General Medicine Consultant in Diabetes & Endocrinology and General Internal Medicine, Wrexham Maelor Hospital
Cho Thae Phyu MRCP-UK CT2 in General Medicine Consultant in Diabetes & Endocrinology and General Medicine, Wrexham Maelor Hospital
L N Rao Bondugulapati MRCP-UK ST6 in Diabetes & Endocrinology Consultant in Diabetes & Endocrinology and General Medicine, Wrexham Maelor Hospital
AN Dixon FRCP-UK Consultant in Diabetes & Endocrinology and General Internal Medicine, Wrexham Maelor Hospital
John Harvey FRCP-UK, Consultant in Diabetes & Endocrinology and General Medicine, Wrexham Maelor Hospital

A Case of Newly Diagnosed Primary Hypothyroidism with Deteriorating Consciousness that did not Respond to Thyroxine – What Else should be Considered?

Cite this article as:

Williams A, Green N, Phyu CT, Bondugulapati R, Dixon AN, Harvey J. A case of newly diagnosed primary hypothyroidism with deteriorating consciousness that did not respond to thyroxine--what else should be considered? Acute Med. 2013;12(2):102-4. PMID: 23732135.

A Case of Newly Diagnosed Primary Hypothyroidism with Deteriorating Consciousness that did not Respond to Thyroxine – What Else should be Considered?

Share this article

Click the icon of the social media platform on which you would like to share this article.


Shopping Basket
Scroll to Top