Malignancy and alcoholic hepatitis are cited as the most common causes of jaundice seen in secondary care. A patient with non-alcohol related jaundice, however, may require extensive investigations and early involvement of specialists. This article utilises a case presenting to the Acute Medical Unit, (AMU) to illustrate the importance of a careful and systematic assessment of non-alcoholic related jaundice.
Kew, Michael C. “Serum aminotransferase concentration as evidence of hepatocellular damage.” The Lancet 355.9204 (2000): 591-592.
Björnsson E, Ismael S, Nejdet S, Kilander A. Severe jaundice in Sweden in the new millennium: causes, investigations, treatment and prognosis. Scand J Gastroenterol. 2003;38(1):86-94.
Whitehead MW, Hainsworth I, Kingham JG. The causes of obvious jaundice in South West Wales: perceptions versus reality. Gut. 2001;48(3):409-13.
Wang L, Hua S. [A retrospective analysis of ultrasonic diagnosis for 360 cases of extrahepatic obstructive jaundice]. Zhonghua Yi Xue Za Zhi. 2014;94(32):2522-4.
Kathemann S, Lainka E, Baba HA, Hoyer PF, Gerner P. Gilbert’s syndrome--a frequent cause of unconjugated hyperbilirubinemia in children after orthotopic liver transplantation. Pediatr Transplant. 2012;16(2):201-4.
Nag DS, Sinha N, Samaddar DP, Mahanty PR. General anesthesia in a patient with Gilbert’s syndrome. J Anaesthesiol Clin Pharmacol. 2011;27(2):253-5
Raza A, Vierling J, Hussain KB. Genetics of drug-induced hepatotoxicity toxicity in Gilbert’s syndrome. Am J Gastroenterol. 2013;108(12):1936-7.
Jeong R, Lee YS, Sohn C, Jeon J, Ahn S, Lim KS. Model for end-stage liver disease score as a predictor of short-term outcome in patients with drug-induced liver injury. Scand J Gastroenterol. 2015;50(4):439-46.
Bradley-Stewart AJ, Jesudason N, Michie K, Winter AJ, Gunson RN. Hepatitis E in Scotland: Assessment of HEV infection in two high-risk patient groups with elevated liver enzymes. J Clin Virol.2015;63:36-7.
Hawkes N. Pork is UK’s main source of hepatitis E infection, briefing hears. BMJ. 2014;349:g6779.
World Gastroenterology Organisation Practice Guidelines: Management of acute viral hepatitis (December 2003)
Kamar et al, Clin Microbiol Rev. 2014 Jan;27(1):116-38}.
Sridhar S, Lau SK, Woo PC. Hepatitis E: A disease of reemerging importance. J Formos Med Assoc. 2015.
Yang D, MoezArdalan K, Collins DP, Chauhan SS, Draganov PV, Forsmark CE, et al. Predictors of malignancy in patients with suspicious or indeterminate cytology on pancreatic endoscopic ultrasound-guided fine-needle aspiration: a multivariate model. Pancreas. 2014;43(6):922-6.
Brown EG, Canter RJ, Bold RJ. Preoperative CA 19-9 kinetics as a prognostic variable in radiographically resectable pancreatic adenocarcinoma. J Surg Oncol. 2014.
Wang L, Hua S. [A retrospective analysis of ultrasonic diagnosis for 360 cases of extrahepatic obstructive jaundice]. Zhonghua Yi Xue Za Zhi. 2014;94(32):2522-4.
Crosara S, D’Onofrio M, De Robertis R, Demozzi E, Canestrini S, Zamboni G, et al. Autoimmune pancreatitis: Multimodality noninvasive imaging diagnosis. World J Gastroenterol. 2014;20(45):16881-90.
Kamisawa, Terumi. “IgG4-positive plasma cells specifically infiltrate various organs in autoimmune pancreatitis.” Pancreas 29.2 (2004):167-168.
Kanno A, Masamune A, Okazaki K, Kamisawa T, Kawa S, Nishimori I, et al. Nationwide epidemiological survey of autoimmune pancreatitis in Japan in 2011. Pancreas. 2015;44(4):535-9.
Crosara S, D’Onofrio M, De Robertis R, Demozzi E, Canestrini S, Zamboni G, et al. Autoimmune pancreatitis: Multimodality noninvasive imaging diagnosis. World J Gastroenterol. 2014;20(45):16881-90.
Bojková M, Dítě P, Dvořáčková J, Novotný I, Floreánová K, Kianička B, et al. Immunoglobulin G4, autoimmune pancreatitis and pancreatic cancer. Dig Dis. 2015;33(1):86-90.
Sah RP, Chari ST, Pannala R, et al. Differences in clinical profile and relapse rate of type 1 versus type 2 autoimmune pancreatitis. Gastroenterology. 2010 Jul;139(1):140-8;
Malignancy and alcoholic hepatitis are cited as the most common causes of jaundice seen in secondary care. A patient with non-alcohol related jaundice, however, may require extensive investigations and early involvement of specialists. This article utilises a case presenting to the Acute Medical Unit, (AMU) to illustrate the importance of a careful and systematic assessment of non-alcoholic related jaundice.
Kew, Michael C. “Serum aminotransferase concentration as evidence of hepatocellular damage.” The Lancet 355.9204 (2000): 591-592.
Björnsson E, Ismael S, Nejdet S, Kilander A. Severe jaundice in Sweden in the new millennium: causes, investigations, treatment and prognosis. Scand J Gastroenterol. 2003;38(1):86-94.
Whitehead MW, Hainsworth I, Kingham JG. The causes of obvious jaundice in South West Wales: perceptions versus reality. Gut. 2001;48(3):409-13.
Wang L, Hua S. [A retrospective analysis of ultrasonic diagnosis for 360 cases of extrahepatic obstructive jaundice]. Zhonghua Yi Xue Za Zhi. 2014;94(32):2522-4.
Kathemann S, Lainka E, Baba HA, Hoyer PF, Gerner P. Gilbert’s syndrome–a frequent cause of unconjugated hyperbilirubinemia in children after orthotopic liver transplantation. Pediatr Transplant. 2012;16(2):201-4.
Nag DS, Sinha N, Samaddar DP, Mahanty PR. General anesthesia in a patient with Gilbert’s syndrome. J Anaesthesiol Clin Pharmacol. 2011;27(2):253-5
Raza A, Vierling J, Hussain KB. Genetics of drug-induced hepatotoxicity toxicity in Gilbert’s syndrome. Am J Gastroenterol. 2013;108(12):1936-7.
Jeong R, Lee YS, Sohn C, Jeon J, Ahn S, Lim KS. Model for end-stage liver disease score as a predictor of short-term outcome in patients with drug-induced liver injury. Scand J Gastroenterol. 2015;50(4):439-46.
Bradley-Stewart AJ, Jesudason N, Michie K, Winter AJ, Gunson RN. Hepatitis E in Scotland: Assessment of HEV infection in two high-risk patient groups with elevated liver enzymes. J Clin Virol.2015;63:36-7.
Hawkes N. Pork is UK’s main source of hepatitis E infection, briefing hears. BMJ. 2014;349:g6779.
World Gastroenterology Organisation Practice Guidelines: Management of acute viral hepatitis (December 2003)
Kamar et al, Clin Microbiol Rev. 2014 Jan;27(1):116-38}.
Sridhar S, Lau SK, Woo PC. Hepatitis E: A disease of reemerging importance. J Formos Med Assoc. 2015.
Yang D, MoezArdalan K, Collins DP, Chauhan SS, Draganov PV, Forsmark CE, et al. Predictors of malignancy in patients with suspicious or indeterminate cytology on pancreatic endoscopic ultrasound-guided fine-needle aspiration: a multivariate model. Pancreas. 2014;43(6):922-6.
Brown EG, Canter RJ, Bold RJ. Preoperative CA 19-9 kinetics as a prognostic variable in radiographically resectable pancreatic adenocarcinoma. J Surg Oncol. 2014.
Wang L, Hua S. [A retrospective analysis of ultrasonic diagnosis for 360 cases of extrahepatic obstructive jaundice]. Zhonghua Yi Xue Za Zhi. 2014;94(32):2522-4.
Crosara S, D’Onofrio M, De Robertis R, Demozzi E, Canestrini S, Zamboni G, et al. Autoimmune pancreatitis: Multimodality noninvasive imaging diagnosis. World J Gastroenterol. 2014;20(45):16881-90.
Kamisawa, Terumi. “IgG4-positive plasma cells specifically infiltrate various organs in autoimmune pancreatitis.” Pancreas 29.2 (2004):167-168.
Kanno A, Masamune A, Okazaki K, Kamisawa T, Kawa S, Nishimori I, et al. Nationwide epidemiological survey of autoimmune pancreatitis in Japan in 2011. Pancreas. 2015;44(4):535-9.
Crosara S, D’Onofrio M, De Robertis R, Demozzi E, Canestrini S, Zamboni G, et al. Autoimmune pancreatitis: Multimodality noninvasive imaging diagnosis. World J Gastroenterol. 2014;20(45):16881-90.
Bojková M, Dítě P, Dvořáčková J, Novotný I, Floreánová K, Kianička B, et al. Immunoglobulin G4, autoimmune pancreatitis and pancreatic cancer. Dig Dis. 2015;33(1):86-90.
Sah RP, Chari ST, Pannala R, et al. Differences in clinical profile and relapse rate of type 1 versus type 2 autoimmune pancreatitis. Gastroenterology. 2010 Jul;139(1):140-8;
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‘Non Surgical’ jaundice- how to manage on the medical take
Cite this article as:
Sinha D, Portal AJ. 'Non Surgical' jaundice - how to manage on the medical take. Acute Med. 2015;14(4):182-7. PMID: 26726790.
‘Non Surgical’ jaundice- how to manage on the medical take
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