Abstract
Avian (H5N1) influenza has been responsible for millions of wild bird and poultry deaths throughout the world. Sporadic human cases with a high mortality have occurred, almost exclusively in association with very close contact with sick, dying or dead birds. Appropriate management of suspected cases requires their prompt recognition via attention to travel and bird-exposure history. The early isolation, diagnosis and treatment of suspected cases as well as prompt involvement of the health protection unit should enable patients to be optimally managed with minimum risk to health care staff.
[download-attachments container="div" style="list" dipslay_icon="1" display_count="1" display__size="0"]
- World Organisation for Animal Health. Update on Influenza in Animals (type H5) September 20, 2006 (accessed April 30, 2007 at http://www.oie.int/downld/AVIAN%20INFLUENZA/A_AI-Asia.htm).
- World Health Organisation. Cumulative Number of Confirmed Human Cases of Avian Influenza A/(H5N1) Reported to WHO. September 27, 2006 (accessed April 30, 2007 at http://www.who.int/csr/disease/avian_influenza/ country/cases_table_2007_04_30/en/index.html.
- Belshe RB The origin of Pandemic Flu – Lessons from the 1918 Virus NEJM 2005; 353; 21: 2209–11.
- Hein TT, Liem NT, Dung NT, et al Avian influenza A (H5N1) in 10 patients in Vietnam. N Engl J Med 2004; 350: 1179–88.
- Chan PKS. Outbreak of Avian Influenza A(H5N1) Virus Infection in Hong Kong in 1997. Clin Infect Dis 2002; 34; Suppl 2: S58–64.
- Chotpitaysunondh T, Ungchusak K, Hansshaoworakul W, et al. Human Disease from Influenza A (H5N1), Thailand, 2004. Emerg Inf Dis 2005; 11: 201–9.
- Writing Committee of the WHO consultation on Human Influenza A/H5 Avian Influenza A (H5N1) infection in Humans. N Engl J Med 2005; 353: 1374–85.
- Bridges CB, Lim W, Hu-Primmer J, et al Risk of influenza A (H5N1) Infection among Poultry Workers, Hong Kong 1997–1998. JID 2002; 185: 1005–10.
- Algorithm for the management of returning travellers and visitors from countries affected by avian influenza (H5N1) presenting with febrile respiratory illness: September 6, 2006 (accessed April 30, 2007) http://www.hpa.org.uk/infections/topics_az/influenza/avian/algorithm.htm
- Ungchusak K, Auewarakul P, Dowell SF, et al. Probable Person-toPerson Transmission of Avian Influenza A (H5N1). N Engl J Med 2005; 352: 333–40.
- Bridges CB, Katz JM, Seto WH, et al Risk of Influenza A (H5N1) Infection among Health Care Workers Exposed to Patients with Influenza A (H5N1), Hong Kong. JID 2000; 181: 344–8.
- Apisarnthanarak A, Kitphati R, Thongphubeth K, et al. Atypical Avian Influenza (H5N1). Emerging infectious Diseases; 10: 1321–4.
- Health Protection Agency. SARS – hospital infection control guidance. November 1, 2005 (accessed April 30, 2007 at http://www.hpa.org.uk/infections/topics_az/SARS/hosp_infect_cont.htm).
- Health Protection Agency. Case definition and guidance on reporting, and management of SARS patients in the UK in the inter-epidemic period. February 21, 2006 (accessed April 30, 2007 at http://www.hpa.org.uk/ infections/topics_az/SARS/casedef.htm#Surveillance).
- Ward P, Small I, Smith J, et al. Oseltamivir and its potential for use in the event of an influenza pandemic JAC 2005; 55; Suppl S1: i5–i21.
- World Health Organisation. Advice on the use of Oseltamivir. March 17, 2006.
- De Jong MD, Thanh TT, Khanh TH, et al. Oseltamivir Resistance during Treatment of Influenza A (H5N1) Infection. N Engl J Med 2005; 353: 2667–72.
- Hayden F, Belshe R, Villanuva C, et al Management of Influenza in Households: A Prospective, Randomised comparison of Oseltamivir Treatment with or without Post Exposure Prophylaxis. JID 2004; 189: 440–9.
- Health Protection Agency. Post-exposure prophylaxis (PEP) for contacts of confirmed human cases of avian influenza (H5N1) in UK. June 19, 2006 (accessed September 27, 2006 at http://www.hpa.org.uk/infections/topics_az/influenza/avian/documents/humancontacts100406.pdf).
