Volume 13

The Perils Of Grandma’s Medication: Colchicine Toxicity causing Pneumomediastinum.

Abstract

A 19 year old male presented with a deliberate overdose of colchicine (50mg). He had no other significant medical history. 36 hours following admission he developed widespread surgical emphysema. An urgent CT scan of his chest and abdomen demonstrated mediastinal gas of lung origin. He also developed bone marrow suppression and disseminated intravascular coagulopathy. He was treated supportively with intravenous fluids, high flow oxygen and intravenous antibiotics and made a full recovery.

Colchicine toxicity is a rare, but important presentation with high levels of morbidity and mortality. Pneumomediastinum is a potentially important complication. It may be appropriate to monitor patients in the later stages of the condition through an ambulatory setting.

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Abstracts from the oral poster sessions at the 8th International Society for Acute Medicine conference

2-3rd October 2014 at the Brighton Centre

The 8th International conference of the Society for Acute Medicine took place on 2-3rd October 2014 at the Brighton Centre. Over 250 abstracts were submitted for consideration and 120 were selected as posters for display during the conference. 11 of these were selected for oral presentation at the conference. The abstracts for these presentations are published here.

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Developing and Evaluating Nurse led Discharge in Acute Medicine

Abstract

Aims: To develop and evaluate nurse-led discharge criteria for a clinical decision unit in a large NHS Foundation Trust

Method: Criteria for nurse led discharge were developed for patients presenting to hospital via the emergency department with chest pain, headache and deliberate self poisoning. Data on length of stay on CDU and readmission were collected for these patient groups during a 2 month period, during which the nurse-led criteria were introduced. Following introduction of the criteria a survey was conducted to evaluate staff opinions of the new system.

Results: A trend towards reduced length of stay was noted during the month after introduction of nurse-led discharge (18.26hrs vs 20 hours p=0.582). Our staff survey indicated that the process was popular and has been continued since the study period.

Conclusion: Nurse-led discharge using defined criteria is feasible and popular with staff in an acute medical setting.

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Does admission via an Acute Medical Unit influence hospital mortality? 12 years’ experience in a large Dublin Hospital

Abstract

Background: Following an emergency medical admission, patients may be admitted an acute medical assessment unit (AMAU) or directly into a ward. An AMAU provides a structured environment for their initial assessment and treatment.

Methods: All emergency admissions (66,933 episodes in 36,271 patients) to an Irish hospital over an 12-year period (2002-2013) were studied with 30-day in-hospital mortality as the outcome measure. Univariate Odds Ratios, by initial patient allocation, and the fully adjusted Odds Ratios were calculated, using a validated logistic regression model.

Results: Patients, by design, were intended to be admitted initially to the AMAU (<= 5 day stay). Capacity constraints dictated that only 39.8% of patients were so admitted; the remainder bypassed the AMAU to a ward (60.2%). All patients remained under the care of the admitting consultant/team. We computed the risk profile for each group, using a multiple variable validated model of 30-day in-hospital mortality; the model indicated the same risk profile between these groups. The univariate OR of an in-hospital death by day 30 for a patient initially allocated to the AMAU, compared with an initial ward allocation was 0.76 (95% CI: 0.71, 0.82- p<0.001). The fully adjusted risk for patients was 0.67 (95% CI: 0.62, 0.73- p<0.001). Conclusion: Patients, with equivalent mortality risk, allocated initially to AMAU or a more traditional ward, appeared to have substantially different outcomes.

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Editorial

Winter has arrived again, and our thoughts turn to the management of pressures associated with surges of respiratory and diarrhoeal illness, when the bed stock of the hospital remains permanently full. The phenomenon of ‘exit block’ is as real a challenge for Acute Medical Units as it is for Emergency Departments (ED), with patients commonly exceeding the desired length of stay in the AMU while awaiting availability of a suitable speciality bed. The problem is compounded by increased numbers of patients whose discharge or transfer is delayed, particularly in the period after Christmas when the backlog for our Social Service colleagues may be considerable. When the AMU becomes gridlocked, there is an inevitable pressure back on the ED, with the consequence that alternative solutions may be sought to avoid breaches of the 4 hour emergency access target. The temptation to move patients directly from the ED to areas of the hospital which are not designed to receive and treat acutely ill medical patients should be resisted, according to the data presented in the paper by Coary et al from Dublin. According to their review of over 36,000 patient admissions over a 12 year period, patients who bypassed the AMU experienced a significantly higher mortality, despite an identical expectation of death according to a multi-variable risk model. Although the authors do not speculate on the precise reason for the difference, which may be multifactorial, this paper provides an important message about the need to maintain a structured process of care, as bed pressures rise across our hospitals.

Structure is also an important part of clinical examination. David Nicholl’s Viewpoint article raises a plea for re-establishment of neurological examination as part of the assessment of patients admitted on the medical take. He reminds us that ‘Neurological Examination NAD’ should imply that it was normal, rather than not actually done. Tendon hammers and ophthalmoscopes are not always easy to find on the acute medical unit (I now carry my own ophthalmoscope in my pocket) – perhaps this is, in part, why it is often easier to reach for a pen and complete a request for an imaging scan rather than checking the reflexes or the patient’s fundi. Given that tendon hammers are considerably cheaper than stethoscopes, it is perhaps surprising that more doctors don’t possess their own.

Finally, I have often thought that rats get an unfairly hard time: the mere sighting of one such rodent in my back garden is usually met with a swift request to lay down poison or call in the extermination team. I once read that we are usually only a matter of a few yards away from a rat, as we go about our day to day existence. With this in mind it is somewhat surprising that our acute medical units are not regularly filled with cases of leptospirosis and Weil’s disease. Perhaps the reason for this is that some cases are going unrecognised – the report from the team at Chelsea and Westminster highlights the non-specific presentation in a patient who was initially thought to have ‘flu, before being treated for atypical pneumonia. The admitting team could be forgiven for missing the history of blackberry picking in the days preceding his admission, which led to a leptospira serological sample being sent; confirmation of the diagnosis occurred after his condition had already been treated. Maintaining an awareness of this condition is important to ensure choice of appropriate antibiotics – and ‘smelling a rat’ sometimes requires a very careful history.

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Correspondence

Please click link below to view the PDF. References I Sanusi. British Society of Echocardiography Adult Accreditation: An Unrealistic Expectation for Acute Physicians? Acute Medicine 2014; 13(2): 84-85 Susanna Price, Gabriele Via, Erik Sloth et al and WINFOCUSECHO-ICU Group. Echocardiography practice, Training and accreditation in the intensive care: document for the World Interactive Network Focused

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Palliative Care – a useful speciality skill for trainees in Acute Medicine

I gained a run through number in ACCS (AIM and GIM) in 2007 when Acute Medicine, both as a training programme and a stand alone medical specialty, was in its infancy. As the programme has evolved and developed it has become a curriculum requirement for trainees to attain an acknowledged specialist skill.

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Problem based review: The Pregnant Woman Presenting to the AMU with Palpitations

Abstract

Pregnant patients commonly present to the acute medical team with symptoms requiring further investigation. Palpitations are a common reason for presentation on the acute medical take, and most acute physicians will be familiar with the process of investigation. The combination of pregnancy and palpitations raises a broad differential diagnosis and can complicate the management pathway. This problem based review is designed to summarise the key issues which may arise during the management of a typical patient presenting in this way.

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Problem based review: The patient with recent onset Polyarthritis

Abstract

A wide variety of conditions can present as acute polyarthritis, ranging from those that are potentially life threatening, to those that are self-limiting, and those that represent the early stages of a persistent and potentially destructive form of arthritis. In this article, we describe the diagnostic approach and initial management of patients with recent onset polyarthritis, with the aid of an illustrative case vignette.

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Trainee Update September 2014

I hope you have all settled well into your new jobs and a very warm welcome to those that have recently joined the ‘family’ of acute medicine. I would first of all like to thank Ruth Johnson for all her hard work as trainee representative over the last 18 months and wish her all the best as she ventures into consultant territory: her replacement will be announced later in the autumn.

July was a busy month, dominated by our Acute Medicine Awareness Week, during which AMUs across the UK undertook events to raise the profile of the speciality and the important work they were doing locally. Barnsley completed a 25 mile virtual marathon, Crosshouse Hospital made £350 in a cake sale, Salford Royal staff walked around every acute medical unit in Greater Manchester, North Staffordshire staff ran a half marathon and there was more cake on sale in Kings College and Leicester Royal. The AMU staff at Southampton raised over £400 with their cake sale and cycle challenge, during which they were joined by the Trust Chief Executive for a ‘virtual’ 120 miles on an exercise bike situated outside the hospital entrance. The highlight, however was the contribution of Dr Nigel Lane, an acute medicine trainee from Southmead Hospital in North Bristol, who put together an outstanding weekly programme of events. This included a visit from the Chief Executive of the trust, visit from local GPs to the unit, daily MDT teaching, daily ‘messages of the day’ located on the trust website and lots of screensavers, banners and information scattered throughout the hospital. I am delighted to announce that Nigel has received the SAM awareness week prize. This involves the opportunity to join the European School of Internal Medicine and attend the winter EFIM school camp in Latvia.

Nigel will also be joining us as one of the speakers in the trainee session at SAM Brighton. He will be speaking on “Preparing for your PYA”. There will also be talks in the trainee session on “Keeping your e-portfolio updated”, “Choosing your specialist skill” and “Preparing for your consultant job”. The session will be aimed at both junior and senior trainees. The trainee that has produced the best poster at Brighton will also have a chance to win a place to attend the summer EFIM school camp. The day before the conference starts there will be a SCE revision session. I attended last year and found it extremely helpful!

Looking forward to seeing you all in Brighton. In the meantime if you have any problems or suggestions please tweet or email me at the addresses below.

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