Disseminated intravascular coagulation in an under-recognised zoonotic infection

Disseminated intravascular coagulation in an under-recognised zoonotic infection

Abstract

A 51 year old man presented with severe sepsis, disseminated intravascular coagulation (DIC) and multiorgan dysfunction after a 24 hour history of diarrhoea and malaise. Despite fluid resuscitation and receiving a platelet transfusion, freshfrozen plasma and intravenous broad-spectrum antibiotics, he remained anuric with a worsening metabolic acidosis. He was transferred to critical care for organ support including renal replacement therapy. He subsequently developed purpura fulminans. Blood cultures were positive for Captocytophaga carnimorsis, a gram-negative canine zoonosis that is an underdiagnosed cause of severe sepsis, for which DIC at presentation is characteristic. Treatment is with penicillins and fluoroquinolones. Identification of risk factors for unusual organisms and recognition of DIC allowing prompt treatment is critical for the acute physician.

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References

  1. Bobo, R. A. & Newton, E. J. A previously undescribed gramnegative bacillus causing septicemia and meningitis. Am. J. Clin. Pathol. 65, 564–9 (1976).
  2. Butler, T. Capnocytophaga canimorsus: an emerging cause of sepsis, meningitis, and post-splenectomy infection after dog bites. Eur. J. Clin. Microbiol. Infect. Dis. 34, 1271–1280 (2015).
  3. Hastbacka, J., Hynninen, M. & Kolho, E. Capnocytophaga canimorsus bacteremia: clinical features and outcomes from a Helsinki ICU cohort. Acta Anaesthesiol. Scand. 60, 1437–1443 (2016).
  4. Pers, C., Gahrn-Hansen, B. & Frederiksen, W. Capnocytophaga canimorsus septicemia in Denmark, 1982-1995: review of 39 cases. Clin. Infect. Dis. 23, 71–5 (1996).
  5. van Dam, A. P. & Jansz, A. Capnocytophaga canimorsus infections in The Netherlands: a nationwide survey. Clin. Microbiol. Infect. 17, 312–315 (2011).
  6. Popiel, K. Y. & Vinh, D. C. ‘Bobo-Newton syndrome’: An unwanted gift from man’s best friend. Can. J. Infect. Dis. Med. Microbiol. 24, 209–214 (2013).
  7. Brenner, D. J., Hollis, D. G., Fanning, G. R. & Weaver, R. E. Capnocytophaga canimorsus sp. nov. (formerly CDC group DF2), a cause of septicemia following dog bite, and C. cynodegmi sp. nov., a cause of localized wound infection following dog bite. J. Clin. Microbiol. 27, 231–5 (1989).
  8. Janda, J. M., Graves, M. H., Lindquist, D. & Probert, W. S. Diagnosing Capnocytophaga canimorsus infections. Emerg. Infect. Dis. 12, 340–342 (2006).
  9. Ma, A. & Goetz, M. B. Capnocytophaga canimorsus Sepsis With Associated Thrombotic Thrombocytopenic Purpura. Am. J. Med. Sci. 345, 78–80 (2013).
  10. Taylor, F. B. et al. Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation. Thromb. Haemost. 86, 1327–30 (2001).
  11. Boral, B. M., Williams, D. J. & Boral, L. I. Disseminated Intravascular Coagulation. Am. J. Clin. Pathol. 146, 670–680 (2016).
  12. Wada, H., Matsumoto, T. & Yamashita, Y. Diagnosis and treatment of disseminated intravascular coagulation (DIC) according to four DIC guidelines. J. intensive care 2, 15 (2014).

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Disseminated intravascular coagulation in an under-recognised zoonotic infection

1st November 2017
PMID: 29072871
Authors Affiliations
Sarah Lawrence MBBS MA (Oxon) MRCP DTMH, CMT2 Bolton Royal Hospital
Andrew Claxton MBChB MSc, ST4 in Intensive Care Medicine, Salford Royal Foundation Trust
Mark Holland Clinical and Biomedical Sciences, Faculty of Health and Wellbeing, University of Bolton, United Kingdom
Jack Hodd MB BChir MRCP, ST5 in Acute Medicine and Intensive Care Medicine, Central Manchester Foundation Trust

Disseminated intravascular coagulation in an under-recognised zoonotic infection

Cite this article as:

Lawrence S, Claxton A, Holland M, Hodd J. Disseminated intravascular coagulation in an under-recognised zoonotic infection. Acute Med. 2017;16(3):138-141. PMID: 29072871.

Disseminated intravascular coagulation in an under-recognised zoonotic infection

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